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GHK-Cus mechanism depends on cumulative tissue signaling rather than peak concentration

A primary challenge lies in SFNs suboptimal pharmacokinetic profile, characterized by rapid metabolism, limited oral bioavailability, and chemical instability

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In addition, in in vitro/in vivo designed project reported that CBD increases levels of mitofusin 2, a mitochondrial fusion protein that plays a role in regulating inflammation and protecting against neurodegeneration